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LAMP3/CD208 (E8T2T) Rabbit mAb #33401
Filter:
- IHC
Immunohistochemical analysis of paraffin-embedded mouse lung using LAMP3/CD208 (E8T2T) Rabbit mAb.
To Purchase # 33401
Cat. #
Size
Price
Inventory
33401T
20 µl
¥1,500
无库存
33401S
100 µl
¥4,990
无库存
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous (IHC-P) |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- M-Mouse
- Related Products
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:100 - 1:400 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
For a carrier free (BSA and azide free) version of this product see product #91340.
For a carrier free (BSA and azide free) version of this product see product #91340.
Protocol
Specificity / Sensitivity
LAMP3/CD208 (E8T2T) Rabbit mAb recognizes endogenous levels of total LAMP3/CD208 protein.
Species Reactivity:
Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn257 of mouse LAMP3/CD208 protein.
Background
Lysosome-associated membrane proteins (LAMPs) are a family of proteins present predominantly on the membrane of lysosomes. Five members have been identified so far (LAMP1, LAMP2, LAMP3, CD68/Macrosialin/LAMP4, and BAD-LAMP/LAMP5). LAMP proteins are involved in many different aspects of cell biology and can influence cellular processes, such as phagocytosis, autophagy, lipid transport, and aging. Their expression varies among different tissues (1). LAMP3, also known as CD-LAMP and CD208, is highly expressed only in certain cell types and differentiation stages. LAMP3 is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation, but is not expressed by DCs in mouse (2-4). Its expression is associated with poor prognosis of certain tumors, and the locus where it is encoded was identified as a risk factor for Parkinson's disease (PD) (5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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