R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
KLF2 (E2Z1H) Rabbit mAb #15306
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 42 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
KLF2 (E2Z1H) Rabbit mAb recognizes endogenous levels of total KLF2 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu108 of human KLF2 protein.
Background
Krüppel-like factors (KLFs) are a family of zinc finger-containing DNA-binding transcriptional regulators that share homology with the Drosophila melanogaster Krüppel protein that regulates body segmentation. Seventeen mammalian KLFs have been identified so far and they regulate diverse biological processes, including development, differentiation, proliferation, growth, survival, and external stress responses. Alterations in their functions have been linked to many human diseases, including metabolic diseases and cancer (1-3). KLF2 is a key regulator in the differentiation and function of immune cells and vascular endothelial cells. KLF2 suppresses NF-κB-mediated gene expression and plays important roles in inflammatory response (4-7).
- McConnell, B.B. and Yang, V.W. (2010) Physiol Rev 90, 1337-81.
- Tetreault, M.P. et al. (2013) Nat Rev Cancer 13, 701-13.
- Bialkowska, A.B. et al. (2017) Development 144, 737-754.
- Jha, P. and Das, H. (2017) Int J Mol Sci 18, 2383. doi: 10.3390/ijms18112383.
- Turpaev, K.T. (2020) Biochemistry (Mosc) 85, 54-67.
- Wittner, J. and Schuh, W. (2021) Vaccines (Basel) 9, 1171. doi: 10.3390/vaccines9101171.
- Dabravolski, S.A. et al. (2022) Biomedicines 10, 254. doi: 10.3390/biomedicines10020254.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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