R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
KK-LC-1 (F3U6C) Rabbit mAb #77593
Filter:
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 14 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
KK-LC-1 (F3U6C) Rabbit mAb recognizes endogenous levels of total KK-LC-1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human KK-LC-1 protein.
Background
Kita-kyushu lung cancer antigen 1 (KK-LC-1), also known as CT83, is a small cancer-associated protein that was first discovered as a tumor-specific antigen in lung cancer (1). KK-LC-1 expression is restricted to the testis, but its aberrant expression has been observed in lung, gastric, liver, and triple-negative breast cancer (1-6). Although its exact biological function is not completely understood, KK-LC-1 is being targeted in multiple immunotherapies, including T cell receptor-engineered T cells (TCR-Ts) (7).
- Fukuyama, T. et al. (2006) Cancer Res 66, 4922-8.
- Hanagiri, T. et al. (2013) Anticancer Res 33, 2123-8.
- Shida, A. et al. (2015) Anticancer Res 35, 3575-9.
- Futawatari, N. et al. (2017) World J Gastroenterol 23, 8200-8206.
- Chen, Z. et al. (2019) Cell Prolif 52, e12581.
- Kondo, Y. et al. (2018) Anticancer Res 38, 5923-5928.
- Marcinkowski, B. et al. (2019) J Immunother Cancer 7, 229.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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