Render Target: SSR
Render Timestamp: 2024-10-24T19:40:39.462Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-08-01 15:28:25.950
Product last modified at: 2024-10-07T23:30:08.124Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

KCNK6 Antibody #92295

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 35, 70
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    KCNK6 Antibody recognizes endogenous levels of total KCNK6 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human KCNK6 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Potassium channels are protein complexes that form potassium ion (K+)-selective pores allowing the passive transport of K+ through biological membranes. They regulate K+ homeostasis and cell volume, and also have physiological functions involved in neurotransmitter and hormone secretion and muscular and neuronal excitability. Many potassium channel proteins have been identified and classified into different groups, mainly based on their membrane topology. The KCNK subfamily (Potassium channel subfamily K) is characterized by the presence of four transmembrane segments (4TMS) and the two-pore (2P) domain (4TMS/2P). These two-pore domain K+ (K2p) channels are considered as leaky channels that maintain background K+ currents to stabilize the negative membrane potential and counterbalance depolarization (1-4).

    KCNK6, also known as TWIK-2, is expressed in all human tissues examined except the skeletal muscle (5). A recent study identified KCNK6 as the K+ channel mediating K+ efflux across the plasma membrane that is essential for NLRP3 inflammasome activation (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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