ITM2C/Bri3 (F3X8Z) Rabbit mAb #88436

The BRI gene family comprises at least three members, BRI1/ITM2A, BRI2/ITM2B, and BRI3/ITM2C, which encode three type II transmembrane glycoproteins BRI1, BRI2, and BRI3, respectively. BRI3 expression is highest in the brain but the protein is also expressed in plasmacytoid dendritic cells, appendix, peripheral blood leukocytes, bone marrow, and fetal liver (1). BRI2 and BRI3 have been reported to negatively regulate amyloid β (Aβ) production by binding to Aβ precursor protein (APP) and inhibiting its processing by secretases. Both proteins mask the cleavage sites of α- and β-secretase on APP. However, unlike BRI2, the binding of BRI3 to the β-secretase cleaved APP C-terminal fragment is negligible (2,3). More recently, the BRI3/ITM2C gene signature has been identified as a potential marker for the early detection of colorectal cancer (4).