R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Integrin α11 (E6O6G) Rabbit mAb #37815
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 160 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Integrin α11 (E6O6G) Rabbit mAb recognizes endogenous levels of total Integrin α11 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys29 of human Integrin α11 protein.
Background
Integrin α11, also known as type I collagen receptor, is a single-pass type I transmembrane protein that mediates cell-matrix adhesion and is part of the family of integrins that play a pivotal role in regulation processes of cell proliferation, differentiation, migration, tumor invasion, and metastasis (1-3). Integrin α11 is highly expressed in embryonic fibroblasts and myofibroblasts and to varying degrees in the cytoplasm of most human tissues (4-6). In non-small cell lung cancers, integrin α11 overexpression correlates with tumorigenicity and formation of secondary metastatic lesions by increasing the migration and invasion capacity (7,8). TGFβ activation of integrin α11 results in significant upregulation and overexpression by cancer associated fibroblasts in the tumor stroma; therefore, it has been used as a prognostic marker in certain cancers (9,10). As a receptor for type I collagen, which is found in fibrotic tissue of the liver, lung, and kidney, integrin α11 colocalizes with α-smooth muscle actin. Type I collagen is the most abundant form in the body, indicating a role for targeting integrin α11 in the therapeutic intervention of fibrotic disease (4).
- Wu, P. et al. (2019) PeerJ 7, e8299.
- Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
- Schnittert, J. et al. (2018) Adv Drug Deliv Rev 129, 37-53.
- Bansal, R. et al. (2017) Exp Mol Med 49, e396.
- Velling, T. et al. (1999) J Biol Chem 274, 25735-42.
- Lehnert, K. et al. (1999) Genomics 60, 179-87.
- Ando, T. et al. (2020) Cancer Sci 111, 200-208.
- Lu, N. et al. (2010) Matrix Biol 29, 166-76.
- Schnittert, J. et al. (2019) FASEB J 33, 6609-6621.
- Parajuli, H. et al. (2017) J Oral Pathol Med 46, 267-275.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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