IGFBP5 (E7P5P) Rabbit mAb #19256
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 32 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
IGFBP5 (E7P5P) Rabbit mAb recognizes endogenous levels of total IGFBP5 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro139 of human IGFBP5 protein.
Background
Insulin-like growth factor (IGF) signaling plays a major role in regulating the proliferation and metabolism of normal and malignant cells. IGF-binding proteins (IGFBPs) play an integral role in modifying IGF actions in a wide variety of cell types. The six IGFBP family members share a high affinity for IGF binding and are structurally related, but are encoded by distinct genes (1). IGFBPs can exert stimulatory or inhibitory effects by controlling IGF availability through high affinity binding of IGF at the carboxy-terminal domain (2,3). IGFBP5 belongs to the high affinity IGF binding family. The effects of IGFBP5 on cancer development are either positive or negative depending on the cancer type (4). IGFBP5 has been shown to regulate tumor cell survival, apoptosis, migration, and metastasis by mechanism of IGF-dependent or IGF-independent actions (4-6). Downregulation of IGFBP5 is associated with therapeutic resistance in breast cancer and esophageal carcinoma. Meanwhile, upregulation of the protein can reverse drug resistance (7-9).
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- Yu, H. and Rohan, T. (2000) J Natl Cancer Inst 92, 1472-89.
- Martin, J.L. and Baxter, R.C. (2011) Growth Factors 29, 235-44.
- Güllü, G. et al. (2012) Chin J Cancer 31, 266-80.
- Hwang, J.R. et al. (2016) Sci Rep 6, 39334.
- Ding, M. et al. (2016) Nat Cell Biol 18, 319-27.
- Chan, D. et al. (2018) Cells 7, pii: E143. doi: 10.3390/cells7100143.
- Wang, W. et al. (2018) Mol Cancer Ther 17, 1973-83.
- Leyh, B. et al. (2015) Oncotarget 6, 39307-28.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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