IgA (N1CLA) Mouse mAb #50384
Filter:
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse IgG1 |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:800 - 1:3200 |
| Immunohistochemistry (Paraffin) | 1:400 - 1:1600 |
Storage
Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
IgA (N1CLA) Mouse mAb recognizes endogenous levels of IgA protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to 129 amino acids of the heavy chain constant region of human immunoglobulin A molecule.
Background
Immunoglobulin A (IgA) is one of the five major human immunoglobulin isotypes and the most abundant immunoglobulin in the mucosal immune system. The structure of IgA consists of two identical heavy chains and two identical light chains, linked by disulfide bonds. Human IgA exists as two subclasses, IgA1 and IgA2, that are structurally different in the flexible hinge region (1). The secreted form of IgA (SIgA) is the predominant mucosal antibody that contains two copies of IgA, a joining-chain (J chain), and a secretory component (SC) (2). IgA antibodies are expressed by B cells and are a part of both the innate and adaptive immune response (3). Since IgA antibodies are secreted by mucosa, they are important when studying autoimmune diseases associated with the gastrointestinal tract (4).
限制使用
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专品专有“专供研究使用”的专专或专似的专专声明， 且未专得美国食品和专品管理局或其他外国或国内专管机专专专任何用途的批准、准专或专可。客专不得将任何专品用于任何专断或治专目的， 或以任何不符合专专声明的方式使用专品。CST 专售或专可的专品提供专作专最专用专的客专，且专用于研专用途。将专品用于专断、专防或治专目的， 或专专售（专独或作专专成）或其他商专目的而专专专品，均需要 CST 的专独专可。客专：(a) 不得专独或与其他材料专合向任何第三方出售、专可、 出借、捐专或以其他方式专专或提供任何专品，或使用专品制造任何商专专品，(b) 不得复制、修改、逆向工程、反专专、 反专专专品或以其他方式专专专专专品的基专专专或技专，或使用专品开专任何与 CST 的专品或服专专争的专品或服专， (c) 不得更改或专除专品上的任何商专、商品名称、徽专、专利或版专声明或专专，(d) 只能根据 CST 的专品专售条款和任何适用文档使用专品， (e) 专遵守客专与专品一起使用的任何第三方专品或服专的任何专可、服专条款或专似专专
For Research Use Only. Not For Use In Diagnostic Procedures.
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