R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
IFI44L (E7A9V) Rabbit mAb #77885
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 47 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
IFI44L (E7A9V) Rabbit mAb recognizes endogenous levels of total IFI44L protein. This antibody detects an 18 kDa band of unknown origin in some cell lines.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe85 of human IFI44L protein.
Background
IFI44L (interferon-induced protein 44-like) is a member of the IFI44 family of IFN-stimulated genes (ISG), which play a role in antiviral activity (1-5). IFI44L is induced by many viruses, including Respiratory Syncytial Virus (RSV) and Influenza A virus (IAV) (3,4). IFI44L may be involved in modulating innate immune responses to inflammation and inhibiting virus replication (1,3,4). IFI44L has been studied in relation to its antimicrobial activity and could be a potential prognostic marker for M. tuberculosis treatment (5). IFI44L may also play a suppressive role in Met/Src signaling in human hepatocellular carcinoma (2).
- Crouse, J. et al. (2015) Nat Rev Immunol 15, 231-42.
- Huang, W.C. et al. (2018) BMC Cancer 18, 609.
- DeDiego, M.L. et al. (2019) J Virol 93, e01159-19. doi: 10.1128/JVI.01159-19.
- Busse, D.C. et al. (2020) J Virol 94, e00297-20. doi: 10.1128/JVI.00297-20.
- Jiang, H. et al. (2021) J Immunol Res 2021, 5599408.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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