HYOU1 Antibody #13452
Filter:
- WB
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 150 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
HYOU1 Antibody recognizes endogenous levels of total HYOU1 protein. This antibody reacts weakly with murine and rat HYOU1.
Species Reactivity:
Human, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human HYOU1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Hypoxia up-regulated protein 1 (HYOU1, ORP150) is an endoplasmic reticulum (ER)-resident stress protein whose expression is upregulated in response to a variety of environmental conditions that promote ER stress (1,2). The amino-terminal region of HYOU1 displays extensive similarity to the ATPase domain of HSP70 family proteins, suggesting that HYOU1 contributes to maintaining proper protein folding and secretion under conditions that promote ER stress (2). Research studies have demonstrated that HYOU1 is cytoprotective and is involved in the inhibition of hypoxia-induced cell death (3).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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