HLA-E (MEM-E/02) Mouse mAb #73269
Filter:
- WB
- IHC
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 43 |
| Source/Isotype | Mouse IgG1 |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:125 - 1:500 |
| Flow Cytometry (Fixed/Permeabilized) | 1:1000 - 1:4000 |
Storage
Supplied in PBS (pH 7.4) containing 15 mM sodium azide. Store at 4°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
HLA-E (MEM-E/02) Mouse mAb recognizes endogenous levels of HLA-E protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant human HLA-E denatured heavy chain.
Background
HLA-E (HLA class I histocompatibility antigen, alpha chain E) is a non-classical MHC molecule that is expressed by B and T lymphocytes, natural killer (NK) cells, and macrophages, and is overexpressed in some tumors (1-3). Classical HLA class I molecules (HLA-A, -B, and -C) are highly polymorphic, affecting the peptide binding region (PBR). HLA-E has limited polymorphism that is restricted to two functional versions (3,5). HLA-E is a ligand of CD94/NKG2A, -B, and -C receptors, which are expressed on NK cells and T cells and play a role in the innate and adaptive immune system (3-5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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