GPVI (E4Y9J) Rabbit mAb #45649

GPVI (GP6, Glycoprotein 6) is a collagen receptor expressed on the platelet surface that plays a key role in platelet activation, procoagulant activity, and subsequent thrombin and fibrin formation (1). On the platelet membrane, GPVI interacts with FcRγ chain to form the GPVI-FcRγ chain complex, which functions in collagen-induced platelet adhesion and activation (2,3). Upon collagen binding to GPVI, the complex is activated, resulting in ITAM domain phosphorylation of the FcRγ chain. The ITAM phosphorylation initiates the activation pathway of the Src family kinases (likely Fyn/Lyn) and Syk, as well as the subsequent activation of phospholipase C-γ2 and PI3K pathways. These activated pathways upregulate platelet adhesion and function (4). Given its important role in platelet activation, GPVI has been considered as a promising target for antithrombotic and antiplatelet treatment (5-7). Platelet activation also contributes to cancer progression (8). Platelet GPVI activated ITAM-signaling favors the extravasation of tumor cells for metastasis (9). Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice, supporting the protein as a potential target for cancer treatment (10).