R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
GPR37L1 (D8F5Q) Rabbit mAb #93782
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 48 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
GPR37L1 (D8F5Q) Rabbit mAb recognizes endogenous levels of total GPR37L1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala53 of human GPR37L1 protein.
Background
GPR37-like receptor (GPR37L1), also known as endothelin B receptor-like protein 2 (ETBR-LP-2) and GPCR/CNS2, is an orphan G protein coupled-receptor (1,2,3). GPR37L1 and its closely related receptor, GPR37, are endothelin receptor-like GPCRs that are highly expressed in the central nervous system. GPR37L1 is broadly expressed in the brain and regulates multiple neuronal functions, including cerebellar development (4). Studies also indicate that GPR37L1 and GPR37 may be receptors for prosaposin and prosaptide. Peptide-dependent modulation of GPR37L1 activity may regulate neuronal and glial survival, as prosaposin is known to exert neuroprotective, neurotrophic, and gliotrophic actions. (5,6).
- Leng, N. et al. (1999) Brain Res Mol Brain Res 69, 73-83.
- Zeng, Z. et al. (1997) Biochem Biophys Res Commun 233, 559-67.
- Valdenaire, O. et al. (1998) FEBS Lett 424, 193-6.
- Marazziti, D. et al. (2013) Proc Natl Acad Sci U S A 110, 16486-91.
- Meyer, R.C. et al. (2013) Proc Natl Acad Sci U S A 110, 9529-34.
- Misasi, R. et al. (2009) Cent Nerv Syst Agents Med Chem 9, 119-31.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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