GAT3 Antibody #25438

The solute carrier 6 (SLC6) gene, also known as the neurotransmitter–sodium-symporter family or Na+/Cl- -dependent transporters, encodes for proteins that regulate neurotransmitter (NTT) transport, including monoamine transmitters serotonin, dopamine, and norepinephrine (SERT), GABA transmitters (GAT1, GAT2, GAT3, and BGT1), and glycine transmitters (GLYT1 and GLYT2) (1). The sodium- and chloride-dependent GABA transporter 3 (GAT3) is encoded by the solute carrier family 6 member 11 (SLC6A11) gene (2). GABA is the principal inhibitory neurotransmitter in the central nervous system and maintains the inhibitory tone that balances out neuronal excitation. This balance between neuronal excitation and inhibition is tightly regulated, in part by the GAT family of GABA transporters. These transporters terminate GABA inhibition by mediating cellular reuptake of GABA at the synaptic cleft. The human genome encodes four GABA transports (GAT-1-4).  GAT-1 is found predominantly in the axon terminals of neurons whereas GAT-3 is expressed in astrocytes (3). Dysfunction of GABA transporters may contribute to diseases such as epilepsy as well as neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease (4-6).