EPHX2 (F9Z3M) Rabbit mAb #37117

Soluble epoxide hydrolase 2 (EPHX2, sEH) is an enzyme member of the α/β hydrolase superfamily important for epoxide metabolism, especially those derived from fatty acids including epoxyeicosatrienoic acids (EETs). EPHX2 contains two functional domains connected by a proline-rich linker: a carboxy-terminal domain is responsible for its epoxide hydrolase activity and an amino-terminal phosphatase domain (1). EPHX2 is widely expressed in the central nervous system and peripheral tissue types, with highest expression found in the kidney and liver (1,2). Mutations in the EPHX2 gene have been linked to familial hypercholesterolemia due to its impact on plasma cholesterol levels (3). Studies have shown that suppression of EPHX2 activity through selective inhibitors promotes anti-inflammatory, cardioprotective, and neuroprotective effects through increased circulating EET levels, implicating EPHX2 as a therapeutic target for several disease conditions (4-6).