R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
DOCK5 (E6R9W) Rabbit mAb #56551
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 215 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
DOCK5 (E6R9W) Rabbit mAb recognizes endogenous levels of total DOCK5 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1863 of human DOCK5 protein.
Background
Rho family small GTPases act as molecular switches, regulating processes such as cell migration, adhesion, proliferation, and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and are inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP (1). DOCK5 (dedicator of cytokinesis 5) is a Rho family GEF that plays an essential role in generating the sealing zone, an osteoclast-specific adhesion structure that mediates bone resorption and is regulated by actin and microtubule cytoskeletal signaling. Due to its role in bone resorption, DOCK5 is a potential therapeutic target for osteoporosis (2-4).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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