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CXCR5 (D6L3C) Rabbit mAb #72172

Filter:
  • IHC
Immunohistochemistry Image 1: CXCR5 (D6L3C) Rabbit mAb
Immunohistochemical analysis of paraffin-embedded normal human lymph node using CXCR5 (D6L3C) Rabbit mAb (IHC Specific) performed on the Leica® BOND™ Rx.

To Purchase # 72172

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous (IHC-P)
MW (kDa)
Source/Isotype Rabbit IgG
Application Key:
  • IHC-Immunohistochemistry 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
IHC Leica Bond 1:50 - 1:200
Immunohistochemistry (Paraffin) 1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

For a carrier-free (BSA and azide free) version of this product see product #99825

Protocol

Specificity / Sensitivity

CXCR5 (D6L3C) Rabbit mAb recognizes endogenous levels of total CXCR5 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domains of human CXCR5 protein.

Background

CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration toward secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4).
For Research Use Only. Not For Use In Diagnostic Procedures.
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