CHGA Antibody #60893
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CHGA Antibody recognizes endogenous levels of total CHGA protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val252 of human CHGA protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Chromogranin A (CHGA) and Chromogranin B (CHGB) are members of the chromogranin/secretogranin family of neuroendocrine secretory proteins. They reside in the secretory vesicles of neurons and endocrine cells and are debated to regulate cargo in the secretory pathway (1,2).
CHGA is also useful as a serological and immunohistological marker for the presence of neuroendocrine tumors (NETs) from various tissue sources (3,4). CHGA may also be useful for the assessment of disease progression (5,6).
CHGA is also useful as a serological and immunohistological marker for the presence of neuroendocrine tumors (NETs) from various tissue sources (3,4). CHGA may also be useful for the assessment of disease progression (5,6).
- Machado, J.D. et al. (2010) Cell Mol Neurobiol 30, 1181-7.
- Dominguez, N. et al. (2018) J Neurochem 144, 241-54.
- Weisbrod, A.B. et al. (2013) Horm Cancer 4, 165-75.
- Annaratone, L. et al. (2014) Endocr Pathol 25, 219-28.
- Ardill, J.E. and Erikkson, B. (2003) Endocr Relat Cancer 10, 459-62.
- Welin, S. et al. (2009) Neuroendocrinology 89, 302-7.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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