R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
CDKN3 (E7O5K) Rabbit mAb #48501
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 23 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CDKN3 (E7O5K) Rabbit mAb recognizes endogenous levels of total CDKN3 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro107 of human CDKN3 protein.
Background
CDKN3 (Cyclin-Dependent Kinase Inhibitor 3)/KAP (Kinase-Associated Phosphatase) is a dual specificity phosphatase that regulates cell cycle progression through dephosphorylation and inhibition of cyclin-dependent kinases (1). CDKN3 promotes cancer cell proliferation and invasion (2-4), as well as resistance to cisplatin (5,6). Overexpression of CDKN3 is associated with tumor progression and poor prognosis in several human cancers (5-9).
- Hannon, G.J. et al. (1994) Proc Natl Acad Sci U S A 91, 1731-5.
- Deng, M. et al. (2016) Mol Med Rep 14, 1523-30.
- Li, Y. et al. (2017) Oncol Res 25, 721-731.
- Yu, H. et al. (2020) Oncol Lett 19, 542-548.
- Wang, J. et al. (2019) Cancer Manag Res 11, 3253-3264.
- Li, W.H. et al. (2020) Eur Rev Med Pharmacol Sci 24, 3614-3623.
- Dai, W. et al. (2020) J Int Med Res 48, 300060520936879.
- Fan, C. et al. (2015) Br J Cancer 113, 1735-43.
- Barrón, E.V. et al. (2015) PLoS One 10, e0137397.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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