CD84 Antibody #41033
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45-80 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CD84 Antibody recognizes endogenous levels of total CD84 protein. This antibody cross-reacts with an unidentified protein of 17 kDa.
Species Reactivity:
Mouse
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala322 of mouse CD84 protein. Antibodies are purified by peptide affinity chromatography.
Background
Cluster of Differentiation 84 (CD84), also known as signaling lymphocytic activation molecule family member 5 (SLAMF5), is a membrane glycoprotein expressed by numerous immune cell types, including hematopoietic progenitor cells, T cells, B cells, NK cells, macrophages, monocytes, dendritic cells, platelets, mast cells, and thymocytes (1-9). CD84 is a homophilic adhesion molecule involved in modulating the activation, differentiation, proliferation, and cytotoxicity of a wide variety of immune cells, and thus is involved in the regulation and interconnection of both the innate and adaptive immune response (6-14). Certain CD84 activities are regulated by the presence or absence of small cytoplasmic adaptor proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (5,14). Alternate splicing results in multiple transcript variants.
- Zaiss, M. et al. (2003) Exp Hematol 31, 798-805.
- de la Fuente, M.A. et al. (1997) Blood 90, 2398-405.
- Krause, S.W. et al. (2000) Biochem J 346 Pt 3, 729-36.
- Romero, X. et al. (2004) Tissue Antigens 64, 132-44.
- Tangye, S.G. et al. (2002) Eur J Immunol 32, 1640-9.
- Álvarez-Errico, D. et al. (2011) J Immunol 187, 5577-86.
- Nanda, N. et al. (2005) Blood 106, 3028-34.
- Tangye, S.G. et al. (2003) J Immunol 171, 2485-95.
- Martin, M. et al. (2001) J Immunol 167, 3668-76.
- Sintes, J. et al. (2010) J Leukoc Biol 88, 687-97.
- Wong, E.B. et al. (2015) J Immunol 194, 4130-43.
- Agod, Z. et al. (2018) Front Immunol 9, 62.
- Cannons, J.L. et al. (2010) Immunity 32, 253-65.
- Wang, N. et al. (2010) J Immunol 185, 5683-7.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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