R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
CD40 (Selicrelumab Biosimilar) Human mAb #32592
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Human IgG2 kappa |
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
CD40 (Selicrelumab Biosimilar) Human mAb is a biosimilar antibody for Selicrelumab. Selicrelumab is a therapeutic human monoclonal antibody with agonistic activity on CD40.
| Endotoxin | <0.1 EU/μg of antibody |
Product Usage Information
This product is intended for research use only (RUO). Optimal dilutions/concentrations should be determined by the end user.
Formulation
Supplied in 1X PBS, BSA and Azide Free.
Storage
Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
Specificity / Sensitivity
CD40 (Selicrelumab Biosimilar) Human mAb was confirmed to bind to its intended target protein Selicrelumab using flow cytometry.
Species Reactivity:
Human
Source / Purification
CD40 (Selicrelumab Biosimilar) Human mAb is produced at Cell Signaling Technology. Selicrelumab is an antibody directed to bind to the extracellular domain of CD40.
Background
CD40, also known as tumor necrosis factor receptor superfamily member 5 (TNFRSF5), is a type I transmembrane protein expressed on the surface of B cells and professional antigen-presenting cells of the immune system, as well as on several non-hematopoietic cell types and cancers (1-4). CD40 interacts with CD40 ligand (CD40L/TNFSF5), which is expressed primarily on activated T cells but has also been reported on blood platelets, mast cells, basophils, NK cells, and B cells (5). Upon engagement with CD40L, CD40 signals through TNF receptor associated factors and MAP kinase signaling pathways, resulting in a wide variety of immune and inflammatory responses, including dendritic cell activation and cross-presentation, T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation (6-8). The CD40/CD40L axis is essential for the initiation and progression of cellular and humoral adaptive immunity, and is an important area of interest in the study of tumor immunology, neurodegenerative diseases, vascular diseases, and inflammatory disorders (9-12).
- Banchereau, J. et al. (1995) Adv Exp Med Biol 378, 79-83.
- Cooke, P.W. et al. (1999) J Pathol 188, 38-43.
- Hakkarainen, T. et al. (2003) Clin Cancer Res 9, 619-24.
- Slobodova, Z. et al. (2011) Neoplasma 58, 189-97.
- Gauchat, J.F. et al. (1993) FEBS Lett 315, 259-66.
- Quezada, S.A. et al. (2004) Annu Rev Immunol 22, 307-28.
- Spriggs, M.K. et al. (1992) J Exp Med 176, 1543-50.
- Elgueta, R. et al. (2009) Immunol Rev 229, 152-72.
- Korniluk, A. et al. (2014) Tumour Biol 35, 9447-57.
- Townsend, K.P. et al. (2005) Eur J Immunol 35, 901-10.
- Hassan, G.S. et al. (2012) Immunobiology 217, 521-32.
- Zhang, B. et al. (2013) Immunol Lett 153, 58-61.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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