CD38 Antibody #92457
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CD38 Antibody recognizes endogenous levels of total CD38 protein.
Species Reactivity:
Mouse
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse CD38 protein. Antibodies are purified by peptide affinity chromatography.
Background
Cyclic ADP-ribose hydrolase 1 (CD38) is a transmembrane protein involved in several important biological processes, including immune response, insulin secretion, and social behavior. Originally described as a glycosylated immune cell surface marker, additional research determined that CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP ribose (cADPR) from NAD (1,2). Under acidic conditions, CD38 also catalyzes the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) from NADP+. Both cADPR and NAADP act as calcium ion mobilizing messengers that target different intracellular Ca2+ stores (3-6). Since CD38 is the primary mammalian NAD+ glycohydrolase responsible for NAD+ metabolism, CD38 may be a valuable therapeutic target for treatment of metabolic diseases regulated by NAD+-dependent pathways (7,8). CD38 has also been considered a possible therapeutic target for antibody-mediated therapy for myeloma and chronic lymphocytic leukemia (9-11).
- Malavasi, F. et al. (2008) Physiol Rev 88, 841-86.
- Jin, D. et al. (2007) Nature 446, 41-5.
- Lee, H.C. et al. (1999) Mol Cell Biochem 193, 89-98.
- Calcraft, P.J. et al. (2009) Nature 459, 596-600.
- Ogunbayo, O.A. et al. (2011) J Biol Chem 286, 9136-40.
- Lee, H.C. (2012) J Biol Chem 287, 31633-40.
- Cantó, C. et al. (2012) Cell Metab 15, 838-47.
- Escande, C. et al. (2013) Diabetes 62, 1084-93.
- Malavasi, F. et al. (2011) Blood 118, 3470-8.
- Deaglio, S. et al. (2010) Semin Cancer Biol 20, 416-23.
- Chillemi, A. et al. (2013) Mol Med 19, 99-108.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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