CD235a/Glycophorin A (JC159) Rabbit mAb #75126
Filter:
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:800 - 1:3200 |
Storage
Supplied in a Tris-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CD235a/Glycophorin A (JC159) Rabbit mAb recognizes endogenous levels of CD235a/Glycophorin A protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with membrane preparations from splenic hairy cell leukemia cells.
Background
CD235a/Glycophorin A, also known as GPA, is one of the major sialoglycoproteins expressed on human red blood cells, specifically in mature erythrocytes and erythroid precursor cells (1). The GPA gene is encoded for both M- and N-blood group antigens. CD235a/Glycophorin A is characterized as a class I transmembrane protein because it has a cleavable signal peptide and a single membrane-spanning domain (2). The CD235a/Glycophorin A protein is required for the high activity structure of AE1/SLC4A1 and plays an important role in the function of the anion exchange protein (3). CD235a/Glycophorin A is a receptor for Hepatitis A virus (HAV), influenza virus, and parvovirus (4-6).
- Gahmberg, C.G. et al. (1984) Proc Natl Acad Sci U S A 81, 6752-6.
- Chasis, J.A. and Mohandas, N. (1992) Blood 80, 1869-79.
- Bruce, L.J. et al. (2004) J Biol Chem 279, 2414-20.
- Sánchez, G. et al. (2004) J Virol 78, 9807-13.
- Ohyama, K. et al. (1991) Biochem Biophys Res Commun 178, 79-84.
- Huang, L.Y. et al. (2014) Curr Opin Virol 7, 108-18.
限制使用
除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。
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For Research Use Only. Not For Use In Diagnostic Procedures.
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