Render Target: SSR
Render Timestamp: 2024-10-24T19:31:55.012Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-30 01:57:30.856
Product last modified at: 2024-09-30T08:01:35.377Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CD11α (E5S9K) Rabbit mAb #26703

Filter:
  • WB
  • IP
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 160
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunohistochemistry (Paraffin) 1:400 - 1:1600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #36769.

    Protocol

    Specificity / Sensitivity

    CD11α (E5S9K) Rabbit mAb recognizes endogenous levels of total CD11α protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val975 of human CD11α protein.

    Background

    CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 (1), F11R/JAM-1 (2,3), and the secreted form of ubiquitin-like protein ISG15 (4). LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration (2,3), cytotoxic T cell co-stimulation (5), cytotoxic NK cell mediated killing (6), leukocyte clearance (7), and antibody-dependent killing by granulocytes and monocytes (8,9). LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (10). High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells (11,12).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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