CD103/ITGAE (EP206) Rabbit mAb #95835
Filter:
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:50 - 1:200 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Supplied in a Tris-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 12 months when stored at 4°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CD103/ITGAE (EP206) Rabbit mAb recognizes endogenous levels of CD103/ITGAE protein. Non-specific staining was observed in kidney proximal tubules by immunohistochemistry.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the residues of human CD103/ITGAE protein.
Background
Cluster of differentiation molecule 103 (CD103)/Integrin, alpha E (ITGAE) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD103/ITGAE is expressed by subsets of CD4+ and CD8+ T cells, dendritic cells, and mast cells in mucosal tissues (1,2). The heterodimer composed of CD103/ITGAE and integrin beta 7 interacts with E-cadherin, a cellular adhesion molecule found on epithelial cells. The CD103/ITGAE and integrin beta 7 complex plays a role in thymocyte proliferation, intestinal T cell homing, and the antitumor immune response (3-5). Studies have shown that the presence of CD103/ITGAE(+) immune cells can be used as markers for a favorable prognosis in different epithelial cancers (6,7).
- Takada, Y. et al. (2007) Genome Biol 8, 215.
- Andrew, D.P. et al. (1996) Eur J Immunol 26, 897-905.
- Kutlesa, S. et al. (2002) J Cell Sci 115, 4505-15.
- Le Floc'h, A. et al. (2007) J Exp Med 204, 559-70.
- Strauch, U.G. et al. (2001) J Immunol 166, 3506-14.
- Kim, Y. et al. (2019) Sci Rep 9, 3808.
- Webb, J.R. et al. (2014) Clin Cancer Res 20, 434-44.
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