R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
CCL18 (F9S6V) Rabbit mAb #23957
Filter:
- WB
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 9 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Flow Cytometry (Fixed/Permeabilized) | 1:200 - 1:800 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CCL18 (F9S6V) Rabbit mAb recognizes endogenous levels of total CCL18 protein. This antibody does not cross-react with CCL3/MIP-1α or CCL4 proteins.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCL18 protein.
Background
C-C motif chemokine ligand 18 (CCL18, PARC, MIP-4, AMAC-1, DC-CK1) is a member of the CC chemokine family involved in signaling and coordinating immune responses (1-3). CCL18 is a secreted protein, primarily expressed by macrophages, monocytes, and dendritic cells (1-3). Th2-associated anti-inflammatory cytokines such as IL-4, IL-13, and IL-10 can polarize macrophages into an M2 phenotype, which induces CCL18 expression (3,4). In cancer, tumor-associated macrophages (TAMs) may secrete large amounts of CCL18, causing an immunosuppressive tumor microenvironment, which can lead to cancer immune evasion (5).
限制使用
除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。
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For Research Use Only. Not For Use In Diagnostic Procedures.
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