ATP5A1 Antibody #18023
Filter:
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 54 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
ATP5A1 Antibody recognizes endogenous levels of total ATP5A1 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu209 of human ATP5A1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
ATP synthase alpha-subunit (ATP5A1) is a component of the mitochondrial complex V, which functions to generate ATP from ADP. Generation of ATP is catalyzed by ATP synthase. ATP synthase is composed of a soluble catalytic core, F1, and a membrane-spanning proton channel, F0. ATP5A1 is one of five different subunits that comprise the catalytic F1 core. Interestingly, ATP5A1 is genetically linked to neurodevelopmental diseases (1). Moreover, the genetically linked mutant forms of C9ORF72, the most common genetic causes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), bind to ATP5A1 and alter its protein expression, suggesting that mitochondrial dysfunction may be a major driver of disease in C9ORF72-linked ALS/FTD (2).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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