ATP1B3 (F4Z2D) Rabbit mAb #10784

The sodium/potassium-transporting ATPase (Na⁺/K⁺-ATPase) is a transmembrane protein that actively pumps sodium ions out of the cell and potassium ions into the cell, establishing electrochemical gradients that are crucial for various cellular functions. The beta subunits are essential for the proper assembly, trafficking, and stability of the Na⁺/K⁺-ATPase, and they also modulate the activity of the alpha subunits (1-3). ATP1B3 is the beta-3 subunit of the Na⁺/K⁺-ATPase. ATP1B3, as part of the Na⁺/K⁺-ATPase, maintains the electrochemical gradients necessary for nerve impulse transmission that facilitates downstream muscle contraction, nutrient uptake, and cell volume regulation (1-3). The Na⁺/K⁺-ATPase is also involved in cell signaling pathways, including those regulating motility and adhesion in normal cells and cancer cells (4-6).

Altered expression of ATP1B3 has been observed in various cancers, suggesting a potential role in tumor progression. It may represent a novel prognostic biomarker in some tumor types, particularly hepatocellular carcinoma, but potentially other tumor types (4-8).