ApoA4 (1D6B6) Mouse mAb #5700
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45 |
| Source/Isotype | Mouse IgG2a |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
ApoA4 (1D6B6) Mouse mAb recognizes endogenous levels of total ApoA4 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant human ApoA4 protein.
Background
Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Chylomicrons are a fundamental class of apolipoproteins containing very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) (1,2).
Apolipoprotein A-IV (ApoA4) is a glycoprotein that exists as a free apolipoprotein in human plasma (3,4). ApoA4 activates the lecithin cholesterol acyl transferase (5-7) to modulate the rate of lipid transfer protein (LTP) activity (7). Additional evidence suggests that ApoA4 may also act as an antioxidant to inhibit LDL oxidation in the atherosclerosis model (8).
Apolipoprotein A-IV (ApoA4) is a glycoprotein that exists as a free apolipoprotein in human plasma (3,4). ApoA4 activates the lecithin cholesterol acyl transferase (5-7) to modulate the rate of lipid transfer protein (LTP) activity (7). Additional evidence suggests that ApoA4 may also act as an antioxidant to inhibit LDL oxidation in the atherosclerosis model (8).
- Kwiterovich, P.O. (2000) Am J Cardiol 86, 5L-10L.
- Hussain, M.M. (2000) Atherosclerosis 148, 1-15.
- Utermann, G. and Beisiegel, U. (1979) Eur J Biochem 99, 333-43.
- Hayashi, H. et al. (1990) J Lipid Res 31, 1613-25.
- Steinmetz, A. and Utermann, G. (1985) J Biol Chem 260, 2258-64.
- Chen, C.H. and Albers, J.J. (1985) Biochim Biophys Acta 836, 279-85.
- Main, L.A. et al. (1996) Biochim Biophys Acta 1300, 17-24.
- Wong, W.M. et al. (2007) Atherosclerosis 192, 266-74.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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