ALDH2 Antibody #18818
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 56 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
ALDH2 Antibody recognizes endogenous levels of total ALDH2 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val348 of human ALDH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Aldehyde dehydrogenase 2 (ALDH2) is a member of the aldehyde dehydrogenase superfamily (1). The enzymes in this family catalyze the oxidation of a variety of aldehydes, leading to their detoxification (1, 2). ALDH2 activation correlates with decreased ischemic heart injury, suggesting an essential role of ALDH2 in cardiac protection from ischemic injury (3). In addition, ALDH2 is the primary enzyme for aldehyde oxidation in hematopoietic stem cells (4). ALDH2 is required for protecting these cells from DNA damage caused by acetaldehyde and has a critical function to counteract genotoxicity (4, 5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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