AKAP11 (E9E6W) Rabbit mAb #77313

AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell (1). Beyond a common amphipathic alpha-helix which is responsible for recruiting the PKA regulatory subunit (RIα, RIIα, RIβ, or RIIβ), individual AKAPs contain additional domains responsible for the recruitment of additional signaling proteins (phosphodiesterases, phosphatases, cytoskeletal components, other kinases, etc.) or restricting the AKAP to a specific subcellular location (1). AKAP11 (also known as AKAP220) was originally identified in testis where it targets PKA to peroxisomes (2). Studies have also found that AKAP11 functions as an autophagy receptor targeting the R1α inhibitory subunit of PKA for degradation through a selective autophagy pathway, leading to an increase in PKA activity during nutrient deprivation (3). Exome sequencing in bipolar disorder patients identified AKAP11 as a risk gene shared with schizophrenia (4).