ABAT Antibody #64430
Filter:
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 56 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
ABAT Antibody recognizes endogenous levels of total ABAT protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly43 of human ABAT protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
4-aminobutyrate aminotransferase (ABAT) is an enzyme localized within the mitochondrial matrix that acts to catabolize γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT deficiency leads to elevated GABA levels and is associated with a variety of neurological afflictions, including mood and cognitive disorders, psychomotor retardation, and seizures (1,2). Genetic variants of ABAT have also been linked to Alzheimer’s disease (3). In addition to the neurological implications, dysregulation of GABA as a consequence of ABAT deficiency has been linked to the pathogenesis of breast and liver cancers (4-6). Collectively, these studies suggest that ABAT may be a therapeutic target for both neurological disorders and some forms of cancer.
- Besse, A. et al. (2015) Cell Metab 21, 417-27.
- Koenig, M.K. and Bonnen, P.E. (2019) JIMD Rep 43, 13-17.
- Zheng, Q. et al. (2021) Mol Neurobiol 58, 1894-1903.
- Opolski, A. et al. (2000) J Exp Clin Cancer Res 19, 383-90.
- Jansen, M.P. et al. (2015) Mol Oncol 9, 1218-33.
- Han, H. et al. (2021) Int J Biochem Cell Biol 141, 106116.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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