PTBP1 Antibody #8776
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Inquiry Info. # 8776
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Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 57, 59 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PTBP1 Antibody recognizes endogenous levels of total PTBP1 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the human PTBP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
PTBP1/hnRNP I belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs) that exert diverse functions in multiple aspects of RNA metabolism (1). PTBP1 is critical for regulating alternative splicing, IRES-mediated translation initiation, and increased stability of a variety of transcripts (2-4). Recently, PTBP1 was found to interact with PSMA3 from the 20S proteasome and is therefore implicated in the process of protein degradation (5,6). PTBP1 is ubiquitously expressed and shuttles between the nucleus and cytoplasm. Cellular localization of PTBP1 and its interactions with various factors determines the diversity of PTBP1 function (4).
- Chen, M. and Manley, J.L. (2009) Nat Rev Mol Cell Biol 10, 741-54.
- Amir-Ahmady, B. et al. (2005) RNA 11, 699-716.
- Gama-Carvalho, M. et al. (2006) Genome Biol 7, R113.
- Sawicka, K. et al. (2008) Biochem Soc Trans 36, 641-7.
- Lee, K.A. et al. (2011) J Biol Chem 286, 41530-8.
- Fedorova, O.A. et al. (2011) Biochem Biophys Res Commun 416, 258-65.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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