Myelin Protein Zero Antibody #57518
Filter:
- WB
- IF
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Frozen) | 1:1600 |
| Immunofluorescence (Immunocytochemistry) | 1:50 - 1:200 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Myelin Protein Zero Antibody recognizes endogenous levels of total Myelin Protein Zero protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val218 of mouse Myelin Protein Zero protein. Antibodies are purified by peptide affinity chromatography.
Background
Myelin Protein Zero (MPZ, myelin P0) is a single pass membrane glycoprotein member of the IgG superfamily (1,2). MPZ is the most abundant myelin protein in the peripheral nervous system and acts as a major structural component of the peripheral myelin sheath (2,3). It has been shown that MPZ is necessary for normal myelin spiraling, compaction, and maintenance, with disruption of the MPZ gene leading to hypomyelination and degradation of associated axons (4).
Mutations in the MPZ gene have been associated with demyelinating peripheral neuropathies including Charcot-Marie-Tooth neuropathy type 1B (CMT1B), Dejerine–Sottas syndrome (DSS), and congenital hypomyelination (CH) (5,6).
Mutations in the MPZ gene have been associated with demyelinating peripheral neuropathies including Charcot-Marie-Tooth neuropathy type 1B (CMT1B), Dejerine–Sottas syndrome (DSS), and congenital hypomyelination (CH) (5,6).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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