KCNE1 Antibody #3486
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- IP
Inquiry Info. # 3486
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Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 15 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
KCNE1 Antibody detects endogenous levels of total KCNE1 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp76 of human KCNE1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Voltage-gated potassium channels play a variety of important roles in human health and disease (1,2). KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, 2, 3, 4, and KCNE1L) that modulate the activity of several voltage-gated K+ channels (3-5). KCNE1 functions as the modulatory β-subunit of the pore-forming α-subunit KCNQ1, and alters several biophysical properties of KCNQ1 channels (6,7). Research studies have shown that several inherited mutations in KCNE1 result in long QT syndrome (8-10) and deafness (11).
- Jespersen, T. et al. (2005) Physiology (Bethesda) 20, 408-16.
- Robbins, J. (2001) Pharmacol Ther 90, 1-19.
- Takumi, T. et al. (1988) Science 242, 1042-5.
- Abbott, G.W. and Goldstein, S.A. (2001) Mol Interv 1, 95-107.
- McCrossan, Z.A. and Abbott, G.W. (2004) Neuropharmacology 47, 787-821.
- Barhanin, J. et al. (1996) Nature 384, 78-80.
- Sanguinetti, M.C. et al. (1996) Nature 384, 80-3.
- Splawski, I. et al. (1997) Nat Genet 17, 338-40.
- Abbott, G.W. and Goldstein, S.A. (2002) FASEB J 16, 390-400.
- Tian, C. et al. (2007) Biochemistry 46, 11459-72.
- Peters, T.A. et al. (2004) Pediatr Nephrol 19, 1194-201.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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