KIFC1 Antibody #12313
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
KIFC1 Antibody recognizes endogenous levels of total KIFC1 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human KIFC1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Kinesin superfamily proteins (KIFs) are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules (e.g., proteins, nucleic acids). The intracellular transport functions of KIFs are fundamentally important for a variety of cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation (1-4). Disruptions to KIF-mediated intracellular transport have been linked with a variety of pathologies, ranging from tumorigenesis to defects in higher order brain function such as learning and memory (4-6).
Kinesin family member C1 (KIFC1/HSET) is a minus-end directed KIF involved in the processing and movement of early endocytic vesicles (7,8), as well as microtubule cross-linking and spindle assembly (9,10).
Kinesin family member C1 (KIFC1/HSET) is a minus-end directed KIF involved in the processing and movement of early endocytic vesicles (7,8), as well as microtubule cross-linking and spindle assembly (9,10).
- Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
- Yu, Y. and Feng, Y.M. (2010) Cancer 116, 5150-60.
- Park, J.J. et al. (2008) Mol Endocrinol 22, 989-1005.
- Hirokawa, N. et al. (2010) Neuron 68, 610-38.
- Yoshimura, Y. et al. (2010) Mol Cell Biol 30, 2206-19.
- Hirokawa, N. and Noda, Y. (2008) Physiol Rev 88, 1089-118.
- Nath, S. et al. (2007) Mol Biol Cell 18, 1839-49.
- Zhu, C. et al. (2005) Mol Biol Cell 16, 3187-99.
- Mountain, V. et al. (1999) J Cell Biol 147, 351-66.
- Cai, S. et al. (2009) Mol Biol Cell 20, 1348-59.
限制使用
除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。
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For Research Use Only. Not For Use In Diagnostic Procedures.
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