R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
T-bet/TBX21 (D6N8B) XP® Rabbit mAb (InTraSeq™ 3' Conjugate 3009) #57412
Filter:
- SCA
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- SCA-Single Cell Analysis
Species Cross-Reactivity Key:
- H-Human
Product Information
Storage
Supplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
T-bet/TBX21 (D6N8B) XP® Rabbit mAb (InTraSeq™ 3' Conjugate 3009) recognizes endogenous levels of total T-bet/TBX21 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly465 of human T-bet/TBX21 protein.
Background
The T-box gene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids (1,2). The T-box genes exhibit diverse temporal and spatial patterns in the developing embryo. Studies have demonstrated members of this family play crucial roles during embryogenesis in a wide range of organisms by regulating cell fate decisions to establish the early body plan and to regulate later processes underlying organogenesis (3-5). Mutations in T-box genes are associated with many developmental defects (6). Recent studies also indicate potential roles in cancer by members of the T-box family (7-9).
T-bet, also as known as TBX21, plays a critical role in development and maintenance of type 1 helper T (Th1) and T-bet deficient mice display impaired Th1 differentiation (10,11).
T-bet, also as known as TBX21, plays a critical role in development and maintenance of type 1 helper T (Th1) and T-bet deficient mice display impaired Th1 differentiation (10,11).
- Wilkinson, D.G. et al. (1990) Nature 343, 657-9.
- Papaioannou, V.E. and Silver, L.M. (1998) Bioessays 20, 9-19.
- Showell, C. et al. (2004) Dev Dyn 229, 201-18.
- Papaioannou, V.E. (2001) Int Rev Cytol 207, 1-70.
- Hoogaars, W.M. et al. (2007) Cell Mol Life Sci 64, 646-60.
- Baldini, A. (2004) Curr Opin Cardiol 19, 201-4.
- Abrahams, A. et al. (2010) IUBMB Life 62, 92-102.
- Rowley, M. et al. (2004) J Mammary Gland Biol Neoplasia 9, 109-18.
- Yang, X.R. et al. (2009) Nat Genet 41, 1176-8.
- Ho, I.C. and Glimcher, L.H. (2002) Cell 109 Suppl, S109-20.
- Peng, S.L. (2006) Cell Mol Immunol 3, 87-95.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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