Render Target: SSR
Render Timestamp: 2024-12-26T19:00:48.194Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-12-02 20:44:10.540
Product last modified at: 2024-12-17T18:54:24.765Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: IHC Control Slides
PDP - Template ID: *******ff9c92b

SignalSlide® Mouse PD-L1 IHC Controls #41965

Important Ordering Details

Custom Ordering Details: Sections are cut freshly upon ordering. Please allow up to three business days for your product to be processed.

    Product Information

    Product Description

    Each control slide contains formalin fixed, paraffin-embedded cell pellets: Raw 264.7 (mPD-L1 negative) and mouse bone marrow-derived macrophages (mPD-L1 positive), which serve as controls for mPD-L1 immunostaining.

    Background

    Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor-infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    SignalSlide is a registered trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.