Render Target: SSR
Render Timestamp: 2024-11-14T22:34:22.526Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-20 06:21:26.168
Product last modified at: 2024-09-20T07:08:13.606Z
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PDP - Template Name: IHC Control Slides
PDP - Template ID: *******ff9c92b

SignalSlide® Cleaved Caspase-3 (Asp175) IHC Controls #8104

    Product Information

    Product Description

    Each control slide contains formalin fixed, paraffin-embedded Jurkat cells, both untreated and treated with etoposide, that serve as a control for cleaved caspase-3 (Asp 175) immunostaining. Western blot analysis was performed on extracts derived from the same cells to verify the efficacy of the etoposide treatment.

    To be used with antibodies: 9664, 9661, 9662, 2035, 9541.

    Background

    Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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