Interleukin-6 (IL-6) #9954
Inquiry Info. # 9954
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Product Information
Product Usage Information
CST recommends using 50-100 ng/ml for stimulation of IL-6 signaling.
Storage
Human IL-6 is supplied in PBS buffer containing 0.1% BSA. Aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. F
Product Description
Human IL-6 cDNA was subcloned into a prokaryotic expression vector, expressed in E. coli, and recombinant human Interleukin-6 (rhIL-6) protein was purified.
| MW (kDa) | 23.7 |
| Purity | >98% |
Source / Purification
Human Recombinant Protein
Background
Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. Its biological activities are shared by other IL-6 family members, such as leukemia inhibitory factor and oncostatin M (1). To exert its biological effects, IL-6 must bind to the IL-6 receptor (IL-6R), composed of two alpha chains (IL-6Rα, 80 kDa) and two beta chains (IL-6Rβ or gp130, 130 kDa). Two moieties of IL-6 and two pairs of these receptor chains form a functional hexameric IL-6R complex. The subsequent intracellular signaling events are activated via gp130, which is the common signal transducer of cytokines related to IL-6. Activation of the IL-6R stimulates at least three major signaling pathways: JAK/STAT, PI-3 kinase, and MAPK signaling pathways (2,3).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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