Mouse OSM Recombinant Protein #76226
Product Information
Storage
Mouse OSM Recombinant Protein is supplied as a lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can further be diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% BSA, 5% HSA, 10% FBS, or 5% Trehalose) is recommended for long-term storage.
Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC
Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC
Product Description
| MW (kDa) | 20.5 |
| Purity | A greater than 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than 0.2 EU / 1 µg mOSM. |
| Activity | The bioactivity of recombinant mOSM was measured by rat embryo brain cells corresponding to a specific activity of >1.0 x 105 units/mg. The ED50 for this effect is <10 ng/mL. |
Source / Purification
Recombinant mouse OSM was expressed in E. coli and is supplied in a lyophilized form.
Background
Oncostatin M (OSM) is a member of the IL-6 family of cytokines that is produced primarily by activated T cells and macrophages (1,2). OSM induces fibroblast proliferation, inhibits tumor cell proliferation, and plays a role in immune regulation (2,3). Mouse OSM binds to the OSM receptor β (OSMRβ) which forms a heteromeric complex with the common IL-6 family receptor subunit, gp130 (4). In contrast, human OSM binds to two distinct receptor complexes, the OSMRβ/gp130 and LIFRβ/gp130 complexes (4). The ability of human OSM to bind to two receptors may explain the overlapping and distinct activities of human OSM and LIF. OSM induces activation of the JAK2, STAT3, and ERK1/2 pathways (5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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