Human WISP2 Recombinant Protein #44695
Product Information
Storage
Human WISP2 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Product Description
| MW (kDa) | 24.4 |
| Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg hWISP2. |
Source / Purification
Recombinant human WISP2 was expressed in E. coli and is supplied in a lyophilized form.
Background
WNT1 inducible signaling pathway protein 2 (WISP2 or CCN5) belongs to the CCN (Cyr61, Ctgf, NOV) family of proteins. It is a cysteine-rich secretory protein that associates with components of the extracellular matrix (1-3). WISP2 is expressed in endoderm, mesoderm, and ectoderm lineages, including primary osteoblasts, fibroblasts, ovaries, testes, and heart cells (3,4). This protein has been found to regulate cell proliferation, adhesion, signaling, wound healing, fibrosis, skeletal development, and metastasis (5). WISP2 promotes the adhesion of osteoblasts, inhibits osteocalcin production, and inhibits fibrinogen binding to integrin receptors (6). WISP2 is normally expressed in both embryonic and adult tissues (7,8).
- Yeger, H. and Perbal, B. (2007) J Cell Commun Signal 1, 159-64.
- Gray, M.R. et al. (2007) J Cell Commun Signal 1, 145-58.
- Perbal, B. (2001) Mol Pathol 54, 57-79.
- Grünberg, J.R. et al. (2018) J Cell Commun Signal 12, 309-318.
- Ji, J. et al. (2014) Oncol Rep 31, 533-9.
- Kumar, S. et al. (1999) J Biol Chem 274, 17123-31.
- Burren, C.P. et al. (1999) J Clin Endocrinol Metab 84, 1096-103.
- Kocialkowski, S. et al. (2001) Anat Embryol (Berl) 203, 417-27.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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