Human TPO Recombinant Protein (mammalian derived) #86116

Thrombopoietin (TPO) is a 332-amino acid glycoprotein produced by the liver, kidney, marrow stroma, and several other tissues (1). This cytokine is responsible for the regulation of platelet production and promotes both the proliferation of megakaryocyte progenitors and their maturation into platelet-producing megakaryocytes by binding to the thrombopoietin receptor (TPOR, c-Mpl) (2-5). The concentration of TPO in the bloodstream is regulated by the TPOR on platelets and megakaryocytes (6). Binding of TPO to the TPOR induces receptor dimerization that leads to phosphorylation and activation of the tyrosine kinase Jak2 (7). Studies have suggested that TPO may be a useful cytokine for the prevention and treatment of thrombocytopenia in cancer patients and for developing new strategies to therapeutically intervene in hematopoiesis (1,5).