Human/Mouse FGF-8 Recombinant Protein #37188
Product Information
Storage
Human/Mouse FGF-8 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Product Description
| MW (kDa) | 22.5 |
| Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg h/mFGF-8. |
| Activity | The bioactivity of recombinant h/mFGF-8 was determined in an NR6R-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 150 ng/mL. |
Source / Purification
Recombinant human/mouse FGF-8 was expressed in E. coli and is supplied in a lyophilized form.
Background
FGF-8 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-8 binds to receptor FGFR1 and functions as a signaling molecule that is involved in many important processes (1,2). FGF-8 is involved in the development of the forebrain and also plays a role in maxillofacial diseases (3,4). It regulates craniofacial structure formation including the teeth, palate, mandible, and salivary glands and decreased expression of FGF-8 results in malformations such as absence of molar teeth, failure to close the palate, and decreased mandible size (4).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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