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PDP - Template Name: Growth Factors and Cytokines
PDP - Template ID: *******9ad1159
  1. Products /
  2. Cytokines & Growth Factors /
  3. Human IL-9 Recombinant Protein

Human IL-9 Recombinant Protein #91974

    Product Information

    Storage

    Human IL-9 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

    Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

    Product Description

    MW (kDa) 14
    Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
    Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hIL-9.
    Activity The bioactivity of recombinant hIL-9 was determined in a M-O7e cell proliferation assay. The ED50 of each lot is less than or equal to 2 ng/ml.

    Source / Purification

    Recombinant human IL-9 was expressed in E. coli and is supplied in a lyophilized form.

    Background

    Interleukin-9 (IL-9) is a pleiotropic cytokine best known as a T cell and mast cell growth factor (1,2). This T cell stimulator is a member of the common γ-chain-receptor cytokine family; other members include IL-2, IL-4, IL-7, IL-15, and IL-21 (1). IL-9 was first associated with the T helper 2 (TH2) phenotype but is expressed by multiple other TH cell subsets, including TH9 cells, TH17 cells, and regulatory T (TReg) cells (1-3). The effects of IL-9 are mediated through a heterotypic receptor complex consisting of IL-9 receptor alpha (IL-9Rα) and the common γ-chain (3,4). Binding of IL-9 initiates signaling cascades that involve the cross-phosphorylation of Jak1 and Jak3, leading to the activation of Stat1, Stat3, and Stat5 (1-3).

    Database Links

    UniProt ID: P15248


    Entrez-Gene Id: 3578


    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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