Human IL-23 Recombinant Protein #16388
Product Information
Storage
Recombinant human IL-23 is supplied as lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.
Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Product Description
| MW (kDa) | 63 |
| Purity | A greater than 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than 1 EU / 1 μg hIL-23. |
| Activity | The bioactivity of hIL-23 was determined by its ability to induce IL-17 secretion by mouse CTLL-2 cells. The ED50 of each lot is 2.324 ng/mL. |
Source / Purification
Recombinant human IL-23 was expressed in 293 cells with a C-terminal His-tag and is supplied in a lyophilized form.
Background
Interleukin-23 (IL-23) is composed of an IL-12B subunit and an IL-23A subunit, making it a heterodimeric cytokine (1). IL-23 is a known inflammatory cytokine and acts as a mediator responsible for Th17 differentiation and its secretion of IL-17 (2). As a member of the IL-12 cytokine family, IL-23 is known to be involved in autoimmune disorders, including psoriasis and arthritis, as well as several gastric-related autoimmune disorders (3). It has also been shown to induce IFN-γ production and NK cell activation and is a dominant cytokine involved in controlling inflammation in peripheral tissues and joints (4).
限制使用
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专品专有“专供研究使用”的专专或专似的专专声明， 且未专得美国食品和专品管理局或其他外国或国内专管机专专专任何用途的批准、准专或专可。客专不得将任何专品用于任何专断或治专目的， 或以任何不符合专专声明的方式使用专品。CST 专售或专可的专品提供专作专最专用专的客专，且专用于研专用途。将专品用于专断、专防或治专目的， 或专专售（专独或作专专成）或其他商专目的而专专专品，均需要 CST 的专独专可。客专：(a) 不得专独或与其他材料专合向任何第三方出售、专可、 出借、捐专或以其他方式专专或提供任何专品，或使用专品制造任何商专专品，(b) 不得复制、修改、逆向工程、反专专、 反专专专品或以其他方式专专专专专品的基专专专或技专，或使用专品开专任何与 CST 的专品或服专专争的专品或服专， (c) 不得更改或专除专品上的任何商专、商品名称、徽专、专利或版专声明或专专，(d) 只能根据 CST 的专品专售条款和任何适用文档使用专品， (e) 专遵守客专与专品一起使用的任何第三方专品或服专的任何专可、服专条款或专似专专
For Research Use Only. Not For Use In Diagnostic Procedures.
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