Human Growth Hormone Recombinant Protein #34117
Product Information
Storage
Human Growth Hormone Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Product Description
| MW (kDa) | 22.3 |
| Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg hGH. |
Source / Purification
Recombinant human Growth Hormone was expressed in E. coli and is supplied in a lyophilized form.
Background
Growth hormone (GH) is a key growth factor secreted by the anterior pituitary gland that binds to the growth hormone receptor (GHR), which is present in many cell types, to exert its biological effects (1,2). GH primarily acts on the liver to stimulate the production and release of IGF-1 which targets metabolism, growth, and differentiation of cartilage, muscle, and bone (2,3). GH can act on differing cell types, muscle, and other tissues to promote lipolysis and increase protein synthesis, calcium retention, and amino acid uptake (4-6). GH deficiencies in children can result in growth failure, short stature, and delayed sexual maturity (7).
- Goffin, V. et al. (1996) Endocr Rev 17, 385-410.
- Le Roith, D. et al. (2001) Endocr Rev 22, 53-74.
- Doessing, S. et al. (2010) J Physiol 588, 341-51.
- Ahmad, A.M. et al. (2003) J Clin Endocrinol Metab 88, 2860-8.
- Caputo, M. et al. (2021) Cells 10, 1376. doi: 10.3390/cells10061376.
- Møller, N. and Jørgensen, J.O. (2009) Endocr Rev 30, 152-77.
- Murrary, P. et al. (2000) Endotext.
限制使用
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专品专有“专供研究使用”的专专或专似的专专声明， 且未专得美国食品和专品管理局或其他外国或国内专管机专专专任何用途的批准、准专或专可。客专不得将任何专品用于任何专断或治专目的， 或以任何不符合专专声明的方式使用专品。CST 专售或专可的专品提供专作专最专用专的客专，且专用于研专用途。将专品用于专断、专防或治专目的， 或专专售（专独或作专专成）或其他商专目的而专专专品，均需要 CST 的专独专可。客专：(a) 不得专独或与其他材料专合向任何第三方出售、专可、 出借、捐专或以其他方式专专或提供任何专品，或使用专品制造任何商专专品，(b) 不得复制、修改、逆向工程、反专专、 反专专专品或以其他方式专专专专专品的基专专专或技专，或使用专品开专任何与 CST 的专品或服专专争的专品或服专， (c) 不得更改或专除专品上的任何商专、商品名称、徽专、专利或版专声明或专专，(d) 只能根据 CST 的专品专售条款和任何适用文档使用专品， (e) 专遵守客专与专品一起使用的任何第三方专品或服专的任何专可、服专条款或专似专专
For Research Use Only. Not For Use In Diagnostic Procedures.
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