Product Information
MW (kDa) | 18.2 |
Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg hCSF-1/M-CSF. |
Activity | The bioactivity of recombinant hCSF-1/M-CSF was determined in an NFS-60 cell proliferation assay. The ED50 of each lot is less than or equal to 10 ng/mL. |
Recombinant human CSF-1/M-CSF was expressed in E. coli and is supplied in a lyophilized form.
Colony stimulating factor 1 (CSF-1)/macrophage colony stimulating factor (M-CSF) is produced by fibroblasts, endothelial cells, stromal cells, macrophages, osteoblasts, and other cell types (1). CSF-1/M-CSF is required for growth and differentiation of monocytes and macrophages (1,2). CSF-1/M-CSF polarizes macrophages into the M2 phenotype where anti-inflammatory IL-10 is produced, rather than the M1 phenotype where inflammatory cytokines are produced. CSF-1/M-CSF also recruits monocytes and enhances angiogenesis by inducing VEGF production (1,2). CSF-1/M-CSF binds to its receptor CSF1R; downstream signaling involves PI3K/Akt, Erk, and Stats 1, 3, and 5 (1,3). An increase in CSF-1/M-CSF expression may contribute to cancer progression, and high plasma CSF-1/M-CSF levels are associated with rheumatoid arthritis (1,4,5).
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Cat. # | Size | Price | Inventory |
---|---|---|---|
35913S | 10 µg |