HTScan^® FGF Receptor 1 Kinase Assay Kit #7420

Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors-FGF receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated and the receptor tyrosine kinase activated (2), resulting in further activation of various downstream signaling molecules and lysosomal degradation. FGFR has peptide substrate specificity similar to other receptor tyrosine kinase members, prefering acidic residues at the -1 to -4 positions and large hydrophobic amino acids at positions +1 and +3 (3).