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XML generation date: 2024-09-20 06:22:31.718
Product last modified at: 2024-11-20T22:15:09.079Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Resiquimod (R-848)

Resiquimod (R-848) #83597

    Product Information

    Product Usage Information

    Resiquimod (R-848) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.06 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 314.4 g/mol
    Purity >98%
    Molecular Formula C17H22N4O2
    CAS 144875-48-9
    Solubility Soluble in DMSO at 30 mg/ml or ethanol at 15 mg/ml with slight warming.

    Background

    Resiquimod (R-848), an antiviral imidazoquinoline, has been shown to activate Toll-like receptor 7 (TLR7) and TLR8 via the MyD88-dependent interleukin 1 receptor (IL-1R)-TLR signaling pathway (1). Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes (2). Similar to CD40, treatment with Resiquimod (R-848) activates B cells and can induce nuclear translocation of NF-κB at a concentration of 1 μg/ml (3).

    限制使用

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